Nonrenewable fuels are widely employed to supply the growing demand for energy around the world. However, these fuels are expensive as a result of rising demand and dwindling availability. The existing methodology for establishing sustainable biofuel processes and supply chains is outdated. Rather than selecting fuel paths that minimize environmental consequences across the life cycle, life cycle concepts are frequently retroactively included in the design process, resulting in incremental environmental improvement. Furthermore, creating sustainable biofuel supply chains necessitates taking into account numerous spatial and temporal scales of economic, environmental, and social aspects.